Botox is the only approved prophylactic chronic migraine medication, although anticonvulsants, tricyclic antidepressants, and beta-blockers are often used off-label in chronic migraine, whereas several are on-label for episodic migraine. More effective treatment for chronic migraine is a great unmet need. Vagal nerve stimulation is approved for epilepsy and depression. Anecdotal reports of epilepsy patients treated… Read more »
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